(S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Base Information

Chemical Name:(S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide
CAS No.:1338779-93-3
Molecular Formula:C₂₈H₃₃F₄N₅O₂
Molecular Weight:547.596
Hs Code.:

(S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Synonyms:(S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

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Chemical Property of (S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

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Technology Process of (S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

There total 15 articles about (S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₅F₄N₅O₃

: 1338779-93-3
(S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 0.25h;

Reference yield:

: 1029623-74-2
(R)-tert-butyl 1-(2-((2,5-difluorophenyl)(imino)methyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

: 1338779-93-3
(S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Guidance literature:: Multi-step reaction with 7 steps

1: xylenes / 150 °C

2: caesium carbonate / N,N-dimethyl-formamide

3: trifluoroacetic acid / dichloromethane

4: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C

5: triethylamine / dichloromethane / 0.25 h / 20 °C

6: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

7: potassium carbonate / methanol / 0.25 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; xylenes;

Reference yield:

: 64248-64-2
2,5-difluorobenzonitrile

: 1338779-93-3
(S)-N-((R)-1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Guidance literature:: Multi-step reaction with 9 steps

1: hydrazine / ethanol / 0.5 h / 20 °C

2: triethylamine / tetrahydrofuran / -5 - 20 °C

3: xylenes / 150 °C

4: caesium carbonate / N,N-dimethyl-formamide

5: trifluoroacetic acid / dichloromethane

6: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C

7: triethylamine / dichloromethane / 0.25 h / 20 °C

8: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

9: potassium carbonate / methanol / 0.25 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; xylenes;