(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

Base Information

Chemical Name:(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide
CAS No.:1000394-85-3
Molecular Formula:C₂₂H₁₉N₃O₄S₃
Molecular Weight:485.609
Hs Code.:

Synonyms:(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

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Chemical Property of (S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

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Technology Process of (S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

There total 4 articles about (S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000394-51-3
(S)-2-(4-nitrophenyl)-1-(2-(thiophen-2-yl)thiazol-4-yl)ethan-1-amine hydrobromide

: 1939-99-7
benzenesulfonyl chloride

: 1000394-85-3
(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 14h;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 1000394-85-3
(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 5 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 0 - 20 °C

With hydrogen bromide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 293291-20-0
(S)-tert-butyl 4-bromo-1-(4-nitrophenyl)-3-oxobutan-2-ylcarbamate

: 1000394-85-3
(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;