2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

Base Information

Chemical Name:2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide
CAS No.:623547-78-4
Molecular Formula:C₁₇H₂₂IN₃O₂S
Molecular Weight:459.351
Hs Code.:

Synonyms:2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

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Technology Process of 2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

There total 3 articles about 2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3587-60-8
Benzyloxymethyl chloride

: 623547-76-2
2-[(4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

: 623547-78-4
2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/jhet.5570400406

Reference yield:

: 14395-90-5
4-tert-butyl-1,3-dihyroimidazole-2-thione

: 623547-78-4
2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / potassium hydroxide / methanol / 1 h / 20 °C

2: 57 percent / aq. sodium hydroxide; iodine / CH₂Cl₂; methanol / 0.25 h / cooling

3: 75 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 3 h / 20 °C

With potassium hydroxide; sodium hydroxide; iodine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1002/jhet.5570400406

Reference yield:

: 623547-73-9
2-[(4-tert-butyl-1H-imidazol-2-yl)thio]acetamide

: 623547-78-4
2-[(1-benzyloxymethyl-4-tert-butyl-5-iodo-1H-imidazol-2-yl)thio]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / aq. sodium hydroxide; iodine / CH₂Cl₂; methanol / 0.25 h / cooling

2: 75 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; iodine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1002/jhet.5570400406