tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Name:tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1395026-65-9
Molecular Formula:C₂₈H₂₆ClN₇O₃
Molecular Weight:544.013
Hs Code.:

Synonyms:tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 6 articles about tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1395026-27-3
4-(2-chlorophenyl)-8-methanesulfinyl-4H-3,4,7,9,9b-pentaazacyclopenta[a]naphthalene 5-one

: 171049-41-5
tert-butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1395026-65-9
tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: at 90 ℃; for 1h;

Reference yield:

: 3320-83-0
o-chlorophenyl isocyanate

: 1395026-65-9
tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 6 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 1.5 h / 90 °C

3.1: acetonitrile / 0.67 h / 80 °C

4.1: hydrogenchloride / 0.25 h / 160 °C / Microwave irradiation

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

6.1: 1 h / 90 °C

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1395026-23-9
3-(2-chlorophenyl)-7-(methylthio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

: 1395026-65-9
tert-butyl 7-{[6-(2-chlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 1.5 h / 90 °C

2: acetonitrile / 0.67 h / 80 °C

3: hydrogenchloride / 0.25 h / 160 °C / Microwave irradiation

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

5: 1 h / 90 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; acetonitrile;