4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline

Base Information

Chemical Name:4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline
CAS No.:914379-06-9
Molecular Formula:C₄₄H₅₃ClN₄O₂Si
Molecular Weight:733.469
Hs Code.:

Synonyms:4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline

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Chemical Property of 4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline

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Technology Process of 4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline

There total 3 articles about 4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 914379-05-8
(R)-((2S,4S,5R)-5-Ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-(6-triisopropylsilanyloxy-quinolin-4-yl)-methanol

: 29133-99-1
4,6-dichloro-2,5-diphenylpyrimidine

: 914379-06-9
4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline

Guidance literature:: With potassium hydroxide; In toluene; at 115 ℃; for 1h;
DOI:10.1021/jo061650+

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 914379-06-9
4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide / 20 °C

2: 80 percent / potassium hydroxide / toluene / 1 h / 115 °C

With 1H-imidazole; potassium hydroxide; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo061650+

Reference yield:

: 4-[(R)-((2S,4S,5R)-5-Ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-hydroxy-methyl]-quinolin-6-ol

: 914379-06-9
4-[(R)-(6-Chloro-2,5-diphenyl-pyrimidin-4-yloxy)-((2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-6-triisopropylsilanyloxy-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide / 20 °C

2: 80 percent / potassium hydroxide / toluene / 1 h / 115 °C

With 1H-imidazole; potassium hydroxide; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo061650+