N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

Base Information

Chemical Name:N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide
CAS No.:937276-28-3
Molecular Formula:C₁₅H₂₂N₂O₅
Molecular Weight:310.35
Hs Code.:

N<sup>β</sup>-(benzyloxycarbonyl)-N<sup>α</sup>-(tert-butoxycarbonyl)-N<sup>β</sup>-(2-hydroxyethyl)hydrazide

Synonyms:N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

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Chemical Property of N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

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Technology Process of N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

There total 2 articles about N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

: 316802-29-6
N^β-(benzyloxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

: 24424-99-5
di-tert-butyl dicarbonate

: 937276-28-3
N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2007.02.102

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 937276-28-3
N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 71.3 percent / triethylamine / tetrahydrofuran / 3 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2007.02.102

Reference yield: 88.0%

: 937276-28-3
N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

: 192725-92-1
N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

Guidance literature:: N^β-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide; With Dess-Martin periodane; In dichloromethane; water; at 20 ℃; for 2.5h;

With tert-butyl methyl ether; sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; water; at 20 ℃; for 0.5h; Further stages.;
DOI:10.1016/j.tet.2007.02.102