(-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid

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Chemical Name:(-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid
CAS No.:1350961-27-1
Molecular Formula:C₂₅H₃₂N₂O₄
Molecular Weight:424.54
Hs Code.:

Synonyms:(-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid

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Chemical Property of (-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid

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Technology Process of (-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid

There total 5 articles about (-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1350847-03-8
(R)-methyl 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoate

: 1350961-27-1
(-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid

Guidance literature:: (R)-methyl 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoate; With sodium hydroxide; In ethanol; at 20 ℃; for 5h;

With hydrogenchloride; In water;
DOI:10.1021/jm201306q

Reference yield:

: 1350847-06-1
(R)-methyl 2-[4-(2-heptylaminoethyl)phenoxy]propanoate

: 1350961-27-1
(-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 18 h / 0 °C / Reflux

2: sodium hydroxide / ethanol / 5 h / 20 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm201306q

Reference yield:

: 1350847-01-6
(R)-methyl 2-[4-(2-heptanoylaminoethyl)phenoxy]propanoate

: 1350961-27-1
(-)-(R)-2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 0.5 h / Reflux; Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 18 h / 0 °C / Reflux

3.1: sodium hydroxide / ethanol / 5 h / 20 °C

With borane-THF; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm201306q