7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine

Base Information

Chemical Name:7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine
CAS No.:155909-15-2
Molecular Formula:C₂₁H₁₆ClNO₃S
Molecular Weight:397.882
Hs Code.:

Synonyms:7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine

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Chemical Property of 7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine

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Technology Process of 7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine

There total 5 articles about 7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77629-83-5,77053-56-6
ethyl 2-bromo-2-(4-methoxyphenyl) acetate

: 155909-15-2
7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaBH₄ / 1.) EtOH, reflux, 2.) EtOH, RT, 8 h

2: 74.3 percent / aq. NaOH / ethanol; tetrahydrofuran / 1 h / Ambient temperature

3: 43.5 percent / PCl₅ / CH₂Cl₂ / 5 h / 70 °C

4: 1.) KH / 1.) THF, 5 h, RT, 2.) THF, RT, 5 h

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentachloride; potassium hydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00036a007

Reference yield:

: 91166-79-9
bis(4-chloro-2-N-pyrrolylphenyl)disulfide

: 155909-15-2
7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaBH₄ / 1.) EtOH, reflux, 2.) EtOH, RT, 8 h

2: 74.3 percent / aq. NaOH / ethanol; tetrahydrofuran / 1 h / Ambient temperature

3: 43.5 percent / PCl₅ / CH₂Cl₂ / 5 h / 70 °C

4: 1.) KH / 1.) THF, 5 h, RT, 2.) THF, RT, 5 h

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentachloride; potassium hydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00036a007

Reference yield:

: 155908-82-0
p-methoxy-α-<<4-chloro-2-(1H-pyrrol-1-yl)phenyl>thio>phenylacetic acid

: 155909-15-2
7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 43.5 percent / PCl₅ / CH₂Cl₂ / 5 h / 70 °C

2: 1.) KH / 1.) THF, 5 h, RT, 2.) THF, RT, 5 h

With phosphorus pentachloride; potassium hydride; In dichloromethane;
DOI:10.1021/jm00036a007