2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester
CAS No.:899429-34-6
Molecular Formula:C₂₂H₃₃NO₄
Molecular Weight:375.508
Hs Code.:

2-(4-<i>tert</i>-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid <i>tert</i>-butyl ester

Synonyms:2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Property of 2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester

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Technology Process of 2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester

There total 5 articles about 2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-tert-butoxycarbonyl-1-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidinium; iodide

: 899429-34-6
2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester

: 13756-42-8
tert-butyl 4-methylbenzoate

Guidance literature:: With cesium hydroxide; In 1,2-dichloro-ethane; at 0 ℃; for 24h;
DOI:10.1246/cl.2006.478

Reference yield:

: 16881-39-3
(S)-2-tert-butyl-1-benzylpyrrolidine-1,2-dicarboxylate

: 899429-34-6
2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10 percent Pd-C / ethyl acetate / 20 °C / 760 Torr

2: NaHCO₃ / acetonitrile / Heating

3: acetonitrile / Heating

4: 42 percent Spectr_. / CsOH / 1,2-dichloro-ethane / 24 h / 0 °C

With cesium hydroxide; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane; acetonitrile; 4: Stevens rearrangement;
DOI:10.1246/cl.2006.478

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 899429-34-6
2-(4-tert-butoxycarbonyl-benzyl)-1-methyl-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂SO₄ / CH₂Cl₂ / 20 °C

2: H₂ / 10 percent Pd-C / ethyl acetate / 20 °C / 760 Torr

3: NaHCO₃ / acetonitrile / Heating

4: acetonitrile / Heating

5: 42 percent Spectr_. / CsOH / 1,2-dichloro-ethane / 24 h / 0 °C

With cesium hydroxide; sulfuric acid; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane; acetonitrile; 5: Stevens rearrangement;
DOI:10.1246/cl.2006.478