(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide

Base Information

Chemical Name:(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide
CAS No.:1413605-99-8
Molecular Formula:C₂₃H₂₄N₄O₄S₂
Molecular Weight:484.6
Hs Code.:

Synonyms:(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide

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Chemical Property of (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide

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Technology Process of (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide

There total 8 articles about (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1413605-93-2
(S)-methyl 2-(N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamoyl)acetate

: 1413605-99-8
(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 75 ℃; for 0.166667h;

Reference yield:

: 1307231-21-5
(S)-tert-butyl 4-bromo-2,3-dihydro-1H-inden-1-ylcarbamate

: 1413605-99-8
(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate / water; N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 3.5 h / 55 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

5: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 75 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate tribasic trihydrate; potassium acetate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1307231-22-6
(S)-tert-butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

: 1413605-99-8
(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate / water; N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 3.5 h / 55 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

4: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 75 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;