(R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

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Chemical Name:(R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol
CAS No.:1255700-80-1
Molecular Formula:C₂₆H₂₈N₆O₃
Molecular Weight:472.547
Hs Code.:

Synonyms:(R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

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Chemical Property of (R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

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Technology Process of (R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

There total 7 articles about (R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1185019-85-5
3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline

: 1255701-48-4
(R)-2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

: 1255700-80-1
(R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Guidance literature:: 3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline; (R)-2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol; With caesium carbonate; palladium diacetate; CyJohnPhos; In 1,2-dimethoxyethane; at 100 ℃; for 2h; Microwave vial; Inert atmosphere;

With ethanol; In 1,2-dimethoxyethane; at 100 ℃; for 1h;

Reference yield:

: 41789-37-1
2,6-dichloro-5-pyridylmethyl chloride

: 1255700-80-1
(R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

3.1: acetic acid / methanol / 0.25 h / 0 °C

3.2: 2.08 h / 20 °C

4.1: caesium carbonate / palladium diacetate; CyJohnPhos / 1,2-dimethoxyethane / 2 h / 100 °C / Microwave vial; Inert atmosphere

4.2: 1 h / 100 °C

With sodium hydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium diacetate; CyJohnPhos; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1185019-82-2
1-(2-methoxy-4-nitrophenyl)-3-methyl-1H-1,2,4-triazole

: 1255700-80-1
(R)-2-(8-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 20 °C / 1551.49 Torr

2.1: caesium carbonate / palladium diacetate; CyJohnPhos / 1,2-dimethoxyethane / 2 h / 100 °C / Microwave vial; Inert atmosphere

2.2: 1 h / 100 °C

With hydrogen; caesium carbonate; palladium 10% on activated carbon; palladium diacetate; CyJohnPhos; In methanol; 1,2-dimethoxyethane; ethyl acetate;