N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide
CAS No.:911492-03-0
Molecular Formula:C₂₀H₂₁FN₆O₄
Molecular Weight:428.423
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

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Chemical Property of N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

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Technology Process of N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

There total 7 articles about N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₇FN₆O₄

: 911492-03-0
N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

Guidance literature:: With 1% Pd/C; hydrogen; In methanol;
DOI:10.1016/j.bmcl.2009.05.098

Reference yield:

: 911493-94-2
2-{1-[(2-chloroethyl)amino]-1-methylethyl}-N-(4-fluorobenzyl)-5,6-dihydroxypyrimidine-4-carboxamide

: 911492-03-0
N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / 1,4-dioxane / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 65 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 65 °C

4: hydrazine / methanol / Heating / reflux

5: toluene-4-sulfonic acid / 1 h / 110 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With hydrogen; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; hydrazine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 911493-95-3
3-(benzyloxy)-N-(4-fluorobenzyl)-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

: 911492-03-0
N-(4-fluorobenzyl)-3-hydroxy-9,9-dimethyl-8-(1,3,4-oxadiazol-2-ylmethyl)-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 65 °C

2: hydrazine / methanol / Heating / reflux

3: toluene-4-sulfonic acid / 1 h / 110 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; hydrazine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;