4-Hydroxybut-2-ynoic acid

Base Information

• Chemical Name: 4-Hydroxybut-2-ynoic acid
• CAS No.: 7218-52-2
• Molecular Formula: C4H4O3
• Molecular Weight: 100.074
• Hs Code.: 2918199090
• Mol file: 7218-52-2.mol

Synonyms:Tetrolicacid, hydroxy- (7CI,8CI);4-Hydroxy-2-butynoic acid;NSC 620042;g-Hydroxytetrolic acid;

Chemical Property of 4-Hydroxybut-2-ynoic acid

Chemical Property:

• Vapor Pressure: 2.83E-05mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 319.2 °C at 760 mmHg
• PKA: 2.09±0.10(Predicted)
• Flash Point: 161 °C
• PSA: 57.53000
• Density: 1.429 g/cm³
• LogP: -0.93330
• Storage Temp.: 2-8°C
• Solubility.: Acetonitrile (Slightly), DMSO (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxybut-2-ynoicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxybut-2-ynoic Acid (cas# 7218-52-2) is a useful reagent for the green preparation of polyseleno-substituted enamines.

Technology Process of 4-Hydroxybut-2-ynoic acid

There total 11 articles about 4-Hydroxybut-2-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,4-dihydroxybut-2-yne (110-65-6) → 4-hydroxy-2-butynoic acid (7218-52-2)

Guidance literature:

With calcium carbonate; In water; at 30 ℃; for 120h; Rhinocladiella atrovirens KY₈₀₁;

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + propargyl alcohol (107-19-7) → 4-hydroxy-2-butynoic acid (7218-52-2)

Guidance literature:

propargyl alcohol; With n-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

carbon dioxide; Inert atmosphere;

DOI:10.1021/jo501594g

Reference yield:

4-(Tetrahydro-pyran-2-yloxy)-but-2-ynoic acid (116053-25-9) → 4-hydroxy-2-butynoic acid (7218-52-2)

Guidance literature:

With Dowex 50W; In methanol;

DOI:10.1021/jo00256a040

upstream raw materials:

4-acetyloxy-2-butynoic acid

3-(tetrahydropyran-2'-yloxy)propyne

methylammonium carbonate

ethylmagnesium bromide

Downstream raw materials:

α.β-diiodo-γ-oxy-crotonic acid

3-chloro-4-hydroxy-trans-crotonic acid

4-chloro-2(5H)-furanone

α-bromo-γ-oxy-crotonic acid