5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one

Base Information

Chemical Name:5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one
CAS No.:1454303-02-6
Molecular Formula:C₁₈H₁₅FN₄O₄
Molecular Weight:370.34
Hs Code.:

Synonyms:5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one

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Chemical Property of 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one

There total 7 articles about 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1454303-09-3
2-phenoxymethyl-6,7-dihydro-5H-oxazolo[5,4-c]pyridin-4-one

: 37554-70-4
2-chloro-5-fluoro-4-methoxy-pyrimidine

: 1454303-02-6
5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one

Guidance literature:: With palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane; at 100 ℃; for 18h; Sealed tube; Inert atmosphere;

Reference yield:

: 1454302-74-9
4-(2-amino-ethyl)-2-phenoxymethyl-oxazole-5-carboxylic acid ethyl ester

: 1454303-02-6
5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 1,4-dioxane; water / 3.5 h / 0 - 20 °C

2: caesium carbonate; palladium diacetate; XPhos / 1,4-dioxane / 18 h / 100 °C / Sealed tube; Inert atmosphere

With palladium diacetate; potassium carbonate; caesium carbonate; XPhos; In 1,4-dioxane; water;

Reference yield:

: 1454302-65-8
5-benzyloxycarbonylamino-2-chloro-3-oxo-pentanoic acid ethyl ester

: 1454303-02-6
5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetonitrile / 72 h / 20 °C

2: trifluoroborane diethyl ether / toluene / 48 h / 150 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 7 h / 20 °C / 760.05 Torr

4: potassium carbonate / 1,4-dioxane; water / 3.5 h / 0 - 20 °C

5: caesium carbonate; palladium diacetate; XPhos / 1,4-dioxane / 18 h / 100 °C / Sealed tube; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; palladium diacetate; trifluoroborane diethyl ether; potassium carbonate; caesium carbonate; triethylamine; XPhos; In 1,4-dioxane; ethanol; water; toluene; acetonitrile;