(2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid

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Chemical Name:(2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid
CAS No.:1442372-03-3
Molecular Formula:C₂₈H₂₄ClN₅O₅S
Molecular Weight:578.048
Hs Code.:

Synonyms:(2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid

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Chemical Property of (2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid

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Technology Process of (2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid

There total 2 articles about (2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 108-31-6
maleic anhydride

: 1387627-09-9
1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol

: 1442372-03-3
(2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid

Guidance literature:: 1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

maleic anhydride; In dichloromethane; for 9.5h; Reflux;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 4-((1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-yl)oxy)-4-oxobut-2-enoic acid (S)-1-phenylethylamine salt

: 1442372-03-3
(2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 0.833333h;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 1442372-03-3
(2Z)-4-{1-[(2-chloro-10H-phenothiazin-10-yl)methyl]-3-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]propoxy}-4-oxobut-2-enoic acid

: (-)-1-(2-chloro-10H-phenothiazin-10-yl)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butan-2-ol

: (+)-1-(2-chloro-10H-phenothiazin-10-yl)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butan-2-ol

Guidance literature:: With water; sodium hydroxide; In dichloromethane; for 4h; Overall yield = 74 %; Overall yield = 1.85 g; Reflux;
DOI:10.1016/j.bmc.2013.04.034