1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate
CAS No.:1252782-12-9
Molecular Formula:C₂₂H₂₀F₃NO₄
Molecular Weight:419.4
Hs Code.:

Synonyms:1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate

There total 1 articles about 1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850374-94-6
1-t-butoxycarbonyl-3-iodo-1H-indole-6-carboxylic acid methyl ester

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1252782-12-9
1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate

Guidance literature:: With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In toluene; at 90 ℃; for 3h; capped vial; Inert atmosphere;

Reference yield:

: 1252782-12-9
1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate

: 1252782-13-0
methyl 3-(3-trifluoromethylphenyl)-1H-indole-6-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1252782-12-9
1-tert-butyl 6-methyl 3-(3-trifluoromethylphenyl)-1H-indole-1,6-dicarboxylate

: 1252782-10-7
3-(3-trifluoromethyl-phenyl)-1-methyl-1H-indole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 1 h / 0 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 45 °C

3.2: pH ~ 4

With lithium hydroxide monohydrate; water; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;