Technology Process of C23H22BrClFNO5
There total 6 articles about C23H22BrClFNO5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-Butyl ethyl malonate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.5h;
3-(6-bromo-3-(bromomethyl)-2-fluorophenoxy)-5-chlorobenzonitrile;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / ISOPROPYLAMIDE / 0.5 h / 50 °C
1.2: 2 h / 125 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / -78 °C
2.2: 2 h / -50 °C
2.3: -78 - 20 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C
4.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C
5.2: 1.5 h / 0 - 20 °C
With
sodium tetrahydroborate; isopropylmagnesium chloride; phosphorus tribromide; sodium hydride;
In
tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / -78 °C
1.2: 2 h / -50 °C
1.3: -78 - 20 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C
3.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C
4.2: 1.5 h / 0 - 20 °C
With
sodium tetrahydroborate; isopropylmagnesium chloride; phosphorus tribromide; sodium hydride;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
