5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

Base Information

• Chemical Name: 5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
• CAS No.: 1258066-89-5
• Molecular Formula: C₁₆H₁₁ClN₂O₅S
• Molecular Weight: 378.793

Synonyms:5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

Chemical Property of 5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

Chemical Property:

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Technology Process of 5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

There total 1 articles about 5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-chloro-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (1258066-88-4) + lithium formate (556-63-8) → 5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (1258066-89-5)

Guidance literature:

5-chloro-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde; lithium formate; With acetic anhydride; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium diacetate; In N,N-dimethyl-formamide; at 52 ℃; for 3h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In methanol; dichloromethane; water;

Reference yield:

(R)-2-amino-3-cyano-N-cyclopentylpropanamide (1258066-86-2) + 5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (1258066-89-5) → (R)-5-chloro-4-((3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylamino)methyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (1258066-90-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

(R)-benzyl 2-amino-3,3-dimethylbutanoate (1258067-17-2) + 5-chloro-4-formyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (1258066-89-5) → (R)-4-((1-(benzyloxy)-3,3-dimethyl-1-oxobutan-2-ylamino)methyl)-5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (1258066-97-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 ℃; for 0.333333h;

upstream raw materials:

5-chloro-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde

lithium formate

Downstream raw materials:

(R)-5-chloro-4-((3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylamino)methyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

(R)-4-((1-(benzyloxy)-3,3-dimethyl-1-oxobutan-2-ylamino)methyl)-5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

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