7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one

Base Information

Chemical Name:7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one
CAS No.:1456809-34-9
Molecular Formula:C₂₀H₁₆O₄
Molecular Weight:320.345
Hs Code.:

Synonyms:7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one

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Chemical Property of 7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one

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Technology Process of 7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one

There total 9 articles about 7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1456809-32-7
3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-7-methoxy-4-methyl-2H-chromen-2-one

: 1456809-34-9
7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 1.16667h; Inert atmosphere;
DOI:10.1039/c3cc44667k

Reference yield:

: 2555-28-4
4-methyl-7-methoxy-2H-1-benzopyran-2-one

: 1456809-34-9
7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 48 h / 0 - 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 1,4-dioxane / 10 h / 60 °C / Inert atmosphere

3: hydrogenchloride / tetrahydrofuran; methanol; water / 11 h / Inert atmosphere

4: boron tribromide / dichloromethane / 1.17 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; ammonium acetate; boron tribromide; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1039/c3cc44667k

Reference yield:

: 90-33-5,79566-13-5
7-hydroxy-4-methyl-chromen-2-one

: 1456809-34-9
7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 16 h / 0 °C / Inert atmosphere; Reflux

2: N-Bromosuccinimide; ammonium acetate / acetonitrile / 48 h / 0 - 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 1,4-dioxane / 10 h / 60 °C / Inert atmosphere

4: hydrogenchloride / tetrahydrofuran; methanol; water / 11 h / Inert atmosphere

5: boron tribromide / dichloromethane / 1.17 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; ammonium acetate; boron tribromide; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; 3: |Sonogashira Cross-Coupling;
DOI:10.1039/c3cc44667k