Technology Process of benzyl (3S,4R)-1-(2-methoxyethyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-3-ylcarbamate
There total 6 articles about benzyl (3S,4R)-1-(2-methoxyethyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-3-ylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3S,4R)-1-(2-methoxyethyl)-4-(3,4,5-trifluorophenyl)pyrrolidine-3-carboxylic acid;
With
diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine;
In
toluene;
at 20 ℃;
for 2h;
Reflux;
benzyl alcohol;
In
toluene;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 16.25 h / 0 - 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.92 h / -78 °C
2.2: 17 h / 0 - 20 °C
3.1: trifluoroacetic acid / toluene / 2.75 h / 0 °C
3.2: 0 - 20 °C
4.1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 1.5 h / 0 °C
4.2: 2 h / 0 - 20 °C
5.1: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine / toluene / 2 h / 20 °C / Reflux
5.2: 3 h / Reflux
With
oxalyl dichloride; diphenylphosphoranyl azide; water; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.92 h / -78 °C
1.2: 17 h / 0 - 20 °C
2.1: trifluoroacetic acid / toluene / 2.75 h / 0 °C
2.2: 0 - 20 °C
3.1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 1.5 h / 0 °C
3.2: 2 h / 0 - 20 °C
4.1: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine / toluene / 2 h / 20 °C / Reflux
4.2: 3 h / Reflux
With
diphenylphosphoranyl azide; water; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
