[2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Base Information

Chemical Name:[2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone
CAS No.:1101145-60-1
Molecular Formula:C₂₄H₂₀N₄O₂
Molecular Weight:396.448
Hs Code.:

Synonyms:[2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Chemical Property:

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Technology Process of [2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

There total 5 articles about [2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1101145-49-6
(2-amino-6-iodoquinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

: 87199-14-2
2-(hydroxymethyl)phenylboronic acid

: 1101145-60-1
[2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 130 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 20780-76-1
5-iodoisatin

: 1101145-60-1
[2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 16 h / 10 - 23 °C

2: tetrahydrofuran / 0.5 h / 25 °C

3: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 130 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; cesium fluoride; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetonitrile; 4: |Suzuki Coupling;

Reference yield:

: 1228311-56-5
tert-butyl 5-iodo-2,3-dioxo-2,3-dihydroindole-1-carboxylate

: 1101145-60-1
[2-amino-6-[2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.5 h / 25 °C

2: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 130 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; cesium fluoride; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetonitrile; 3: |Suzuki Coupling;