Catramilast

Base Information

Chemical Name:Catramilast
CAS No.:183659-72-5
Molecular Formula:C₁₇H₂₂N₂O₃
Molecular Weight:302.373
Hs Code.:
UNII:QVZ4XA556B
ChEMBL ID:CHEMBL2104960
DSSTox Substance ID:DTXSID40171460
NCI Thesaurus Code:C78124
Mol file:183659-72-5.mol

Synonyms:Catramilast;183659-72-5;Catramilast [USAN:INN];UNII-QVZ4XA556B;QVZ4XA556B;R115500;3-[(2S)-2-[3-(cyclopropylmethoxy)-4-methoxyphenyl]propyl]-1H-imidazol-2-one;2H-Imidazol-2-one, 1-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)propyl)- 1,3-dihydro-, (S)-;R-115500;1-((2S)-2-(3-(Cyclopropylmethoxy)-4-methoxyphenyl)propyl)-1,3-dihydro-2H-imidazol-2-one;Catramilast [USAN];1-[(2S)-2-[3-(Cyclopropylmethoxy)-4-methoxyphenyl]propyl]-1,3-dihydro-2H-imidazol-2-one;R 115500;CATRAMILAST [INN];Catramilast (USAN/INN);CATRAMILAST [WHO-DD];CHEMBL2104960;DTXSID40171460;D06575;R/115500;Q27287525

Suppliers and Price of Catramilast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CATRAMILAST 95.00%
5MG
$ 503.43

Total 6 raw suppliers

Chemical Property of Catramilast

Chemical Property:

PKA:12.34±0.70(Predicted)
PSA：56.25000
Density:1.170 g/cm³
LogP:2.77750
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:302.16304257
Heavy Atom Count:22
Complexity:422

Purity/Quality:

98%Min ^*data from raw suppliers

CATRAMILAST 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CN1C=CNC1=O)C2=CC(=C(C=C2)OC)OCC3CC3
Isomeric SMILES:C[C@H](CN1C=CNC1=O)C2=CC(=C(C=C2)OC)OCC3CC3
Uses Treatment of atopic dermatitis.

Technology Process of Catramilast

There total 5 articles about Catramilast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(3-cyclopropylmethoxy-4-methoxy-phenyl)-propionitrile

: 183659-72-5
1-[2-[3-(cyclopropylmethoxy)-4-methoxyphenyl]propyl]-1,3-dihydro-2H-imidazol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: H₂; NH₃ / Raney Ni / methanol / 20 °C

2: Et₃N / CH₂Cl₂ / 20 °C

3: Et₃N; DMAP / dioxane / Heating

4: 0.5 N HCl / methanol; H₂O / 20 °C

With hydrogenchloride; dmap; ammonia; hydrogen; triethylamine; nickel; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/S0960-894X(01)00817-4

Reference yield:

: 183660-44-8
1-[2-(3-cyclopropylmethoxy-4-methoxy-phenyl)-propyl]-3-(2,2-dimethoxy-ethyl)-urea

: 183659-72-5
1-[2-[3-(cyclopropylmethoxy)-4-methoxyphenyl]propyl]-1,3-dihydro-2H-imidazol-2-one

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃;
DOI:10.1016/S0960-894X(01)00817-4

Reference yield:

: 183660-42-6
2-(3-cyclopropylmethoxy-4-methoxy-phenyl)-propylamine

: 183659-72-5
1-[2-[3-(cyclopropylmethoxy)-4-methoxyphenyl]propyl]-1,3-dihydro-2H-imidazol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: Et₃N; DMAP / dioxane / Heating

3: 0.5 N HCl / methanol; H₂O / 20 °C

With hydrogenchloride; dmap; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/S0960-894X(01)00817-4