Technology Process of 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-6-hydroxy-4-methoxybenzaldehyde
There total 10 articles about 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-6-hydroxy-4-methoxybenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trichloride;
In
hexane; dichloromethane;
at -20 - -5 ℃;
Inert atmosphere;
DOI:10.1039/c1cc11919b
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / dimethyl sulfoxide / 7 h / 20 °C / Cooling; Inert atmosphere
2.1: N-Bromosuccinimide / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere
3.1: pyridine; sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.2: 4 h / -78 - -5 °C / Inert atmosphere
5.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere
6.1: manganese(IV) oxide / toluene / 2 h / Reflux
7.1: boron trichloride / hexane; dichloromethane / -20 - -5 °C / Inert atmosphere
With
pyridine; manganese(IV) oxide; N-Bromosuccinimide; n-butyllithium; sulfuryl dichloride; potassium tert-butylate; boron trichloride; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1039/c1cc11919b
- Guidance literature:
-
Multi-step reaction with 2 steps
1: manganese(IV) oxide / toluene / 2 h / Reflux
2: boron trichloride / hexane; dichloromethane / -20 - -5 °C / Inert atmosphere
With
manganese(IV) oxide; boron trichloride;
In
hexane; dichloromethane; toluene;
DOI:10.1039/c1cc11919b
