(4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole

Base Information

Chemical Name:(4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole
CAS No.:1340476-82-5
Molecular Formula:C₂₁H₂₆N₂O
Molecular Weight:322.45
Hs Code.:

Synonyms:(4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole

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Chemical Property of (4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole

Chemical Property:

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Technology Process of (4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole

There total 4 articles about (4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1340477-06-6
(4R)-4,5-dihydro-2-(2'-bromophenyl)-4-(2-methylpropyl)-oxazole

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1340476-82-5
(4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole

Guidance literature:: With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 120 ℃; for 40h; Inert atmosphere;
DOI:10.1055/s-0030-1260124

Reference yield:

: 7533-40-6,16369-17-8,53448-09-2,502-32-9,14438-11-0
2-amino-4-methyl-1-pentanol

: 1340476-82-5
(4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride / chlorobenzene / 130 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 40 h / 120 °C / Inert atmosphere

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc(II) chloride; sodium t-butanolate; In chlorobenzene; toluene; 2: Buchwald-Hartwig amination reaction;
DOI:10.1055/s-0030-1260124

Reference yield:

: 2042-37-7
o-cyanobromobenzene

: 1340476-82-5
(4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isobutyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride / chlorobenzene / 130 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 40 h / 120 °C / Inert atmosphere

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc(II) chloride; sodium t-butanolate; In chlorobenzene; toluene; 2: Buchwald-Hartwig amination reaction;
DOI:10.1055/s-0030-1260124