3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime

Base Information

• Chemical Name: 3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime
• CAS No.: 1440957-93-6
• Molecular Formula: C₁₈H₁₅ClN₂O
• Molecular Weight: 310.783
• Mol file: 1440957-93-6.mol

Synonyms:3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime

Chemical Property of 3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime

There total 4 articles about 3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

[3-chloro-3-(1-benzyl-1H-indol-3-yl)prop-2-enylidene]dimethyliminium perchlorate → 3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime (1440957-93-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 60 ℃; for 6h;

DOI:10.1016/j.ejmech.2013.03.022

Reference yield:

3-acetylindole (703-80-0) → 3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime (1440957-93-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol / 20 °C

1.2: 0.08 h / 20 °C

2.1: trichlorophosphate / 0.5 h / 0 °C

2.2: 3 h / 0 - 20 °C

2.3: Cooling with ice

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 60 °C

With hydroxylamine hydrochloride; sodium acetate; potassium hydroxide; trichlorophosphate; In ethanol; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.ejmech.2013.03.022

Reference yield:

3-acetyl-1-benzyl-1H-indole (93315-38-9) → 3-(1-benzyl-1H-indol-3-yl)-3-chloro-2-propenal oxime (1440957-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.5 h / 0 °C

1.2: 3 h / 0 - 20 °C

1.3: Cooling with ice

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 60 °C

With hydroxylamine hydrochloride; sodium acetate; trichlorophosphate; In ethanol; 1.1: |Vilsmeier-Haack Formylation / 1.2: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.ejmech.2013.03.022

upstream raw materials:

3-acetylindole

3-acetyl-1-benzyl-1H-indole

benzyl bromide

Downstream raw materials:

6-(1-bBenzyl-1H-indol-3-yl)-4-(4-methoxyphenoxy)thieno[3,2-d]pyrimidine

6-(1-benzyl-1H-indol-3-yl)-4-(4-methoxybenzyl)thieno[3,2-d][1,2,3]triazine

6-(1-benzyl-1H-indol-3-yl)-2-(1-piperidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

6-(1-benzyl-1H-indol-3-yl)-2-(4-morpholinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one