Technology Process of 4-(p-methylphenyl)-3-cyclohexen-1-ol
There total 7 articles about 4-(p-methylphenyl)-3-cyclohexen-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(1-bromoethenyl)-4-methylbenzene; pinacol vinylboronate;
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate;
In
1,4-dioxane; water;
at 50 ℃;
for 1h;
Inert atmosphere;
Sealed tube;
In
1,4-dioxane; water;
at 150 ℃;
for 23h;
Inert atmosphere;
Sealed tube;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 1h;
Overall yield = 64 %; Overall yield = 30.2 mg; regioselective reaction;
DOI:10.1055/s-0037-1611228
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bromine / chloroform / 1 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate / tetrahydrofuran; methanol / 6 h / 20 °C / Inert atmosphere
3.1: palladium diacetate; potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 1 h / 50 °C / Inert atmosphere; Sealed tube
3.2: 23 h / 150 °C / Inert atmosphere; Sealed tube
3.3: 1 h / 0 - 20 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; bromine; palladium diacetate; potassium carbonate;
In
tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water;
3.1: |Suzuki-Miyaura Coupling / 3.2: |Diels-Alder Cycloaddition;
DOI:10.1055/s-0037-1611228
