6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide
CAS No.:1378428-99-9
Molecular Formula:C₃₈H₄₆BFN₂O₇S
Molecular Weight:704.668
Hs Code.:

6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Synonyms:6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

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Technology Process of 6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

There total 18 articles about 6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 1378428-99-9
6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl amine; acetic acid / water / 1 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate; methanol / 0 °C / Inert atmosphere

3: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 0.08 h

4: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere

5: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride / tetrahydrofuran / 3 h / Inert atmosphere

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; potassium carbonate; acetic acid; dimethyl amine; triphenylphosphine; carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 1378428-99-9
6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridinium chlorochromate / dichloromethane / 3.75 h / 0 - 25 °C

2: dimethyl amine; acetic acid / water / 1 h / Inert atmosphere; Reflux

3: sodium tetrahydroborate; methanol / 0 °C / Inert atmosphere

4: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 0.08 h

5: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere

6: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride / tetrahydrofuran / 3 h / Inert atmosphere

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; potassium carbonate; acetic acid; dimethyl amine; triphenylphosphine; pyridinium chlorochromate; carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;