Chemical Property of Vatalanib Dihydrochloride
Chemical Property:
- Appearance/Colour:White to off-white crystalline powder
- Vapor Pressure:7.94E-16mmHg at 25°C
- Melting Point:268-270 °C
- Boiling Point:624 °C at 760 mmHg
- Flash Point:331.2 °C
- Storage Temp.:Refrigerator
- Solubility.:Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
- Purity/Quality:
-
99%, *data from raw suppliers
Vatalanib Dihydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Statements:
36/37/38
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Description
Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.
-
Uses
Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic. Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.
