2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester

Base Information

Chemical Name:2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester
CAS No.:143371-22-6
Molecular Formula:C₃₈H₄₅NO₇S₂
Molecular Weight:691.91
Hs Code.:

Synonyms:2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester

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Chemical Property of 2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester

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Technology Process of 2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester

There total 6 articles about 2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 773-64-8
2-mesitylenesulphonyl chloride

: 143371-20-4
N-((E)-(1S,7S)-7,8-Dihydroxy-1-phenyl-oct-3-enyl)-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

: 143371-22-6
2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester

Guidance literature:: With pyridine; for 48h; Ambient temperature;
DOI:10.1021/ja00047a008

Reference yield:

: 124944-47-4
{(S)-3-[(4-Methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propyl}-triphenyl-phosphonium; iodide

: 143371-22-6
2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium, LiBr / tetrahydrofuran / 0.75 h / 0 °C

2: 2.) phenyllithium, 3.) t-BuOK

3: 96 percent / CH₃COOH, H₂O / tetrahydrofuran / 1 h / Ambient temperature

4: 80 percent / pyridine / 48 h / Ambient temperature

With pyridine; n-butyllithium; potassium tert-butylate; water; acetic acid; phenyllithium; lithium bromide; In tetrahydrofuran;
DOI:10.1021/ja00047a008

Reference yield:

: 42890-81-3
(4S)-4,5-(isopropylidenedioxy)-1-pentanal

: 143371-22-6
2,4,6-Trimethyl-benzenesulfonic acid (E)-(2S,8S)-2-hydroxy-8-[(4-methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-8-phenyl-oct-5-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) phenyllithium, 3.) t-BuOK

2: 96 percent / CH₃COOH, H₂O / tetrahydrofuran / 1 h / Ambient temperature

3: 80 percent / pyridine / 48 h / Ambient temperature

With pyridine; potassium tert-butylate; water; acetic acid; phenyllithium; In tetrahydrofuran;
DOI:10.1021/ja00047a008