3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester
• CAS No.: 182576-28-9
• Molecular Formula: C₃₁H₃₈N₆O₁₀S₂
• Molecular Weight: 718.809

Synonyms:3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester

Chemical Property of 3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester

There total 6 articles about 3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,6-bis-(bromomethyl)pyridine (7703-74-4) + [4-(2-Nitro-benzenesulfonylamino)-butyl]-[3-(2-nitro-benzenesulfonylamino)-propyl]-carbamic acid tert-butyl ester (182576-26-7) → 3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1(18),14,16-triene-7-carboxylic acid tert-butyl ester (182576-28-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1016/0040-4039(96)01627-9 DOI:10.1021/ja964153r

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → 3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1(18),14,16-triene-7-carboxylic acid tert-butyl ester (182576-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 73 percent / Cs₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja964153r

Reference yield:

tert butyl (4 aminobutyl)(3-aminopropyl)carbamate (182576-24-5) → 3,12-Bis-(2-nitro-benzenesulfonyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1(18),14,16-triene-7-carboxylic acid tert-butyl ester (182576-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 73 percent / Cs₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja964153r

upstream raw materials:

2,6-bis-(bromomethyl)pyridine

[4-(2-Nitro-benzenesulfonylamino)-butyl]-[3-(2-nitro-benzenesulfonylamino)-propyl]-carbamic acid tert-butyl ester

N-(3-aminopropyl)-1,4-diaminobutane

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

3,12-Bis-(3-trifluoromethyl-benzyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester

3,12-Bis-(3-nitro-benzyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester

3,12-Bis-(3-methoxycarbonyl-benzyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester

3,12-Bis-(3-trifluoromethyl-benzyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene

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