4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Base Information

Chemical Name:4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole
CAS No.:1221502-51-7
Molecular Formula:C₁₄H₁₄BrF₃N₂
Molecular Weight:347.178
Hs Code.:

Synonyms:4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

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Chemical Property of 4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

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Technology Process of 4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

There total 7 articles about 4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1221503-46-3
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]butan-2-one

: 1221502-51-7
4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Guidance literature:: With diethylamino-sulfur trifluoride; In toluene; at 40 ℃; for 30h; Cooling with ice;
DOI:10.1016/j.bmc.2014.07.038

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1221502-51-7
4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 3 h / 40 °C

2.1: triethylamine; trifluoroacetic acid / isopropyl alcohol / 1 h / 80 °C

3.1: N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

4.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / 20 °C

5.1: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

6.1: Dess-Martin periodane / toluene / 12 h / 0 - 20 °C

7.1: diethylamino-sulfur trifluoride / toluene / 30 h / 40 °C / Cooling with ice

With N-Bromosuccinimide; diethylamino-sulfur trifluoride; sulfur trioxide pyridine complex; sodium hydride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; isopropyl alcohol; toluene; acetonitrile; 6.1: |Dess-Martin Oxidation;
DOI:10.1016/j.bmc.2014.07.038

Reference yield:

: 1221503-47-4
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]butan-2-ol

: 1221502-51-7
4-bromo-1-(3,3-difluorobutyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / toluene / 12 h / 0 - 20 °C

2: diethylamino-sulfur trifluoride / toluene / 30 h / 40 °C / Cooling with ice

With diethylamino-sulfur trifluoride; Dess-Martin periodane; In toluene; 1: |Dess-Martin Oxidation;
DOI:10.1016/j.bmc.2014.07.038