(S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide

Base Information

Chemical Name:(S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide
CAS No.:1329627-20-4
Molecular Formula:C₁₅H₂₀N₂OS₂
Molecular Weight:308.469
Hs Code.:

Synonyms:(S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide

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Technology Process of (S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide

There total 3 articles about (S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: C₈H₁₂N₂OS₂

: 6921-34-2
benzylmagnesium chloride

: 1329627-20-4
(S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide

Guidance literature:: In diethyl ether; dichloromethane; at -50 - 25 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1002/asia.201100338

Reference yield: 53.0%

: 3034-53-5,215777-74-5
2-bromo-1,3-thiazole

: 1207946-42-6
(S)-N-(2-phenylethylidene)-tert-butylsulfinamide

: 1329627-20-4
(S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide

: C₁₅H₂₀N₂OS₂

Guidance literature:: 2-bromo-1,3-thiazole; With n-butyllithium; In hexane; toluene; at -78 ℃; for 0.5h;

(S)-N-(2-phenylethylidene)-tert-butylsulfinamide; In hexane; toluene; for 3h;
DOI:10.1039/c7ob01395g

Reference yield:

: 122-78-1
phenylacetaldehyde

: 1329627-20-4
(S)-2-methyl-N-((S)-2-phenyl-1-(thiazol-2-yl)ethyl)propane-2-sulfinamide

: C₁₅H₂₀N₂OS₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(II) sulfate; pyridinium p-toluenesulfonate / dichloromethane / 36 h / 20 °C

2.1: n-butyllithium / hexane; toluene / 0.5 h / -78 °C

2.2: 3 h

With n-butyllithium; pyridinium p-toluenesulfonate; copper(II) sulfate; In hexane; dichloromethane; toluene;
DOI:10.1039/c7ob01395g