ethyl 4-(3-methoxy-4-methylphenyl)butanoate

Base Information

• Chemical Name: ethyl 4-(3-methoxy-4-methylphenyl)butanoate
• CAS No.: 122334-01-4
• Molecular Formula: C₁₄H₂₀O₃
• Molecular Weight: 236.311
• Mol file: 122334-01-4.mol

Synonyms:ethyl 4-(3-methoxy-4-methylphenyl)butanoate

Chemical Property of ethyl 4-(3-methoxy-4-methylphenyl)butanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 4-(3-methoxy-4-methylphenyl)butanoate

There total 6 articles about ethyl 4-(3-methoxy-4-methylphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(3-methoxy-4-methylphenyl)butanoic acid (122334-02-5) → ethyl 4-(3-methoxy-4-methylphenyl)butanoate (122334-01-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; under 2844.3 Torr; Ambient temperature;

DOI:10.1021/jm00129a029

Reference yield: 98.0%

5-bromo-2-methylphenol methyl ether (67868-73-9) + (4-ethoxy-4-oxobutyl)zinc(II) bromide (151073-69-7) → ethyl 4-(3-methoxy-4-methylphenyl)butanoate (122334-01-4)

Guidance literature:

5-bromo-2-methylphenol methyl ether; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

(4-ethoxy-4-oxobutyl)zinc(II) bromide; In tetrahydrofuran; at 50 ℃; for 5h; Inert atmosphere;

Reference yield: 98.0%

5-bromo-2-methylphenol methyl ether (67868-73-9) + zinc ethyl 4-bromobutyrate → ethyl 4-(3-methoxy-4-methylphenyl)butanoate (122334-01-4)

Guidance literature:

5-bromo-2-methylphenol methyl ether; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

zinc ethyl 4-bromobutyrate; In tetrahydrofuran; at 50 ℃; for 5h;

upstream raw materials:

4-(3-methoxy-4-methylphenyl)butanoic acid

methyl 4-methyl-3-methoxybenzoate

4-(chloromethyl)-2-methoxy-1-methylbenzene

ethyl acrylate

Downstream raw materials:

4-(3-methoxy-4-methylphenyl)butanoic acid