methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate

Base Information

• Chemical Name: methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate
• CAS No.: 1067232-99-8
• Molecular Formula: C₂₀H₂₃ClO₃
• Molecular Weight: 346.854
• Mol file: 1067232-99-8.mol

Synonyms:methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate

Chemical Property of methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate

There total 2 articles about methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

1-(2-methyl-5-phenyl-4,5-dihydrofuran-3-yl)ethanone (13463-61-1) + C13H28O3Si2 (1067232-93-2) → methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate (1067232-99-8)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2008.07.049

Reference yield: 51.0%

1-(2-methyl-5-phenyl-4,5-dihydrofuran-3-yl)ethanone (13463-61-1) + 1,3-bis(trimethylsiloxy)-1-methoxyhexa-1,3-diene (146430-62-8) → methyl 5-(2-chloro-2-phenylethyl)-3-ethyl-4,6-dimethylsalicylate (1067232-99-8)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201000158

upstream raw materials:

1-(2-methyl-5-phenyl-4,5-dihydrofuran-3-yl)ethanone

C₁₃H₂₈O₃Si₂

1,3-bis(trimethylsiloxy)-1-methoxyhexa-1,3-diene