Olmesartan Ethyl Ester

Base Information

• Chemical Name: Olmesartan Ethyl Ester
• CAS No.: 144689-23-6
• Molecular Formula: C₂₆H₃₀N₆O₃
• Molecular Weight: 474.563
• UNII: Y65XBJ935H
• ChEMBL ID: CHEMBL326400
• Nikkaji Number: J715.877G
• Mol file: 144689-23-6.mol

Synonyms:Olmesartan Ethyl Ester;144689-23-6;Olmesartan Acid Ethyl Ester;Olmesartan Ethyl Ester Impurity;CHEMBL326400;Ethyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate;Ethyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate;RYYGFMDEVYVZGY-UHFFFAOYSA-N;SCHEMBL986792;Y65XBJ935H;SCHEMBL16872344;BDBM50049115;HY-131279;CS-0131989;F19428;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester;4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid Ethyl Ester;5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3-[2''-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester;Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate;ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate;ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl) [1,1'-biphenyl]-4-yl]methyl]-imidazole-5-carboxylate

Chemical Property of Olmesartan Ethyl Ester

Chemical Property:

• Boiling Point: 717.6±70.0 °C(Predicted)
• PKA: 4.15±0.10(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 474.23793884
• Heavy Atom Count: 35
• Complexity: 686

Purity/Quality:

97% ^*data from raw suppliers

OlmesartanAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC)C(C)(C)O
• Uses: Olmesartan Acid Ethyl Ester is a impurity of Olmesartan Acid, an angiotensin II receptor antagonist.

Technology Process of Olmesartan Ethyl Ester

There total 20 articles about Olmesartan Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate (172875-59-1) → ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate (144689-23-6)

Guidance literature:

With acetic acid; at 80 ℃; for 2.5h;

DOI:10.1021/jm950450f

Reference yield: 91.16%

ethyl 4-(1-hydroxy-1-methylethyl)-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-2-propyl-1H-imidazole-5-carboxylate → ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate (144689-23-6)

Guidance literature:

With 5% palladium on barium sulphate; sodium formate; In water; isopropyl alcohol; at 55 ℃; for 4h; Reagent/catalyst; Time;

Reference yield: 91.0%

1-[{2'-cyanobiphenyl-4-yl}methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazol-5-carboxylic acid ethyl ester (144690-96-0) → ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate (144689-23-6)

Guidance literature:

upstream raw materials:

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

2-propyl-1H-imidazole-4,5-dicarboxylic acid

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate

Downstream raw materials:

potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate

trityl olmesartan medoxomil

olmesartan medoxomil

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate