[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione

Base Information

• Chemical Name: [3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione
• CAS No.: 20477-00-3
• Molecular Formula: C₂₀H₂₂N₄O₃S
• Molecular Weight: 398.486

Synonyms:[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione

Chemical Property of [3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione

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Technology Process of [3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione

There total 1 articles about [3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylglyoxal hydrate (1074-12-0) + N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-thioxo-butyl)-formamide; sodium salt (4710-54-7) → [3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione (20477-00-3)

Guidance literature:

Multistep reaction; (i) CO₂, EtOH, (ii) /BRN= 1854721/;

DOI:10.1248/cpb.17.128

Reference yield:

[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione (20477-00-3) → thiamine thiazolone (490-82-4)

Guidance literature:

With sodium hydroxide; air; for 10h; Ambient temperature;

DOI:10.1248/cpb.17.128

Reference yield:

[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-yl]-phenyl-ethanedione (20477-00-3) + acetic anhydride (108-24-7) → 1-acetoxy-1-[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazol-2-ylidene]-2-phenyl-ethanone (22283-80-3)

Guidance literature:

In pyridine; water; at 10 - 15 ℃;

DOI:10.1248/cpb.17.128

upstream raw materials:

phenylglyoxal hydrate

N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-thioxo-butyl)-formamide; sodium salt

Downstream raw materials:

thiamine thiazolone

2-acetoxy-2-[5-(2-acetoxy-ethyl)-3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-4-methyl-3H-thiazol-2-ylidene]-1-phenyl-ethanone

1-acetoxy-1-[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazol-2-ylidene]-2-phenyl-ethanone

1-[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazol-2-ylidene]-1-benzoyloxy-2-phenyl-ethanone

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