2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid

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Chemical Name:2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid
CAS No.:1608150-74-8
Molecular Formula:C₇₉H₁₀₆N₁₆O₁₇
Molecular Weight:1551.81
Hs Code.:

2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid

Synonyms:2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid

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Chemical Property of 2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid

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Technology Process of 2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid

There total 1 articles about 2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: cyclo[DKP-RGD]benzylamine

: 1608150-73-7
4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tertbutoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanoic acid

: 1608150-74-8
2-((1S,5S,11S,15R)-18-(4-((4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanamido)methyl)benzyl)-11-(3-guanidinopropyl)-4,7,10,13,17,19-hexaoxo-3,6,9,12,16,18-hexaazabicyclo[13.2.2]nonadecan-5-yl)acetic acid

Guidance literature:: 4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tertbutoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanoic acid; With N-hydroxysulfosuccinimide sodium salt; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere; Schlenk technique;

cyclo[DKP-RGD]benzylamine; In aq. phosphate buffer; acetonitrile; at 0 ℃; for 18h; pH=7.5; Inert atmosphere; Schlenk technique;
DOI:10.1039/c4ob00207e