N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

Base Information

Chemical Name:N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide
CAS No.:1616380-29-0
Molecular Formula:C₂₁H₂₂FN₅O₅
Molecular Weight:443.435
Hs Code.:

Synonyms:N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

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Chemical Property of N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

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Technology Process of N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

There total 4 articles about N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-26-7
N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

: 1616380-29-0
N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1616380-29-0
N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 0.5 h / 80 °C

2: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

3: hydrogenchloride / butan-1-ol; water / 5 h / Reflux

4: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; tetrahydrofuran / 20 °C

With hydrogenchloride; osmium(VIII) oxide; palladium on activated charcoal; hydrogen; caesium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; water; butan-1-ol;

Reference yield:

: 16365-27-8
2-(4-nitrophenoxy)ethanol

: 1616380-29-0
N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

2: hydrogenchloride / butan-1-ol; water / 5 h / Reflux

3: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; tetrahydrofuran / 20 °C

With hydrogenchloride; osmium(VIII) oxide; palladium on activated charcoal; hydrogen; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; water; butan-1-ol;