N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide

Base Information

Chemical Name:N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide
CAS No.:195453-81-7
Molecular Formula:C₂₀H₂₅N₃O₆S
Molecular Weight:435.501
Hs Code.:

Synonyms:N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide

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Technology Process of N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide

There total 7 articles about N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.1%

: 195453-81-7
N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide

Guidance literature:

Reference yield: 41.0%

: 116753-51-6
3-(3-nitrophenoxy)-1-aminopropane

: 195453-77-1
Methanesulfonic acid 7-methanesulfonylamino-chroman-2-ylmethyl ester

: 195453-81-7
N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 16h;
DOI:10.1021/jm9703653

Reference yield:

: 30192-21-3
ethyl 7-amino-4-oxo-4H-1-benzopyran-2-carboxylate

: 195453-81-7
N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / H₂, AcOH / 10percent Pd/C / 120 h / 2585.7 Torr

2: 82 percent / LiBH₄ / tetrahydrofuran / 1.4 h / 0 - 20 °C

3: 90 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 41 percent / K₂CO₃, NaI / dimethylformamide / 16 h / 80 °C

With pyridine; lithium borohydride; hydrogen; potassium carbonate; acetic acid; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9703653