4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid

Base Information

• Chemical Name: 4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid
• CAS No.: 38632-73-4
• Molecular Formula: C₁₃H₁₄O₅
• Molecular Weight: 250.251
• Mol file: 38632-73-4.mol

Synonyms:4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid

Chemical Property of 4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid

There total 6 articles about 4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H12O5 (1569642-44-9) → 4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid (38632-73-4)

Guidance literature:

With acetic acid; zinc; In water; at 20 ℃; for 3h;

DOI:10.1039/c3ra47927g

Reference yield:

Cinnamic acid (621-82-9) → 4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid (38632-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate; methanol / 48 h / Reflux

With methanol; palladium 10% on activated carbon; ammonium formate; 2: |Friedel-Crafts Alkylation;

DOI:10.1039/c3ra47927g

Reference yield:

3-Phenylpropionic acid (501-52-0) → 4-[4-(2-carboxy-ethyl)-phenyl]-4-oxo-butyric acid (38632-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C

2: zinc; acetic acid / water / 3 h / 20 °C

With aluminum (III) chloride; acetic acid; zinc; In dichloromethane; water; 1: |Friedel-Crafts Alkylation;

DOI:10.1039/c3ra47927g

upstream raw materials:

4-[4-(2-ethoxycarbonyl-ethyl)-phenyl]-4-oxo-butyric acid

ethyl dihydrocinnamate

Cinnamic acid

3-Phenylpropionic acid

Downstream raw materials:

C₁₉H₂₂O₇

allyl 4-(4-(3-(allyloxy)-3-oxopropyl)phenyl)-4-oxobutanoate

Refernces