Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate

Base Information

• Chemical Name: Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate
• CAS No.: 348636-04-4
• Molecular Formula: C₂₀H₂₃N₃O₅
• Molecular Weight: 385.42
• Mol file: 348636-04-4.mol

Synonyms:Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate

Chemical Property of Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate

There total 4 articles about Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-methyl-4-(N-benzylamino)-but-2-enoate (131489-59-3) + 1-(4-Chloro-2,6-dimethoxypyrimidin-5-yl)ethanone (348636-14-6) → Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate (348636-04-4)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 72h;

DOI:10.1039/b007163n

Reference yield:

methyl-4-bromo-2-butenoate (1117-71-1,56699-18-4,6000-00-6) → Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate (348636-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / diethyl ether / 24 h / 0 °C

2: 82 percent / Et₃N / CHCl₃ / 72 h / 20 °C

With triethylamine; In diethyl ether; chloroform;

DOI:10.1039/b007163n

Reference yield:

1-(6-Chloro-2,4-dimethoxypyrimidin-5-yl)ethanol (134221-49-1) → Methyl (E)-4-[(5-acetyl-2,6-dimethoxypyrimidin-4-yl)(benzyl)amino]but-2-enoate (348636-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / PCC / CH₂Cl₂ / 6 h / 20 °C

2: 82 percent / Et₃N / CHCl₃ / 72 h / 20 °C

With triethylamine; pyridinium chlorochromate; In dichloromethane; chloroform;

DOI:10.1039/b007163n

upstream raw materials:

(E)-methyl-4-(N-benzylamino)-but-2-enoate

1-(4-Chloro-2,6-dimethoxypyrimidin-5-yl)ethanone

methyl-4-bromo-2-butenoate

1-(6-Chloro-2,4-dimethoxypyrimidin-5-yl)ethanol

Downstream raw materials:

9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-5-methyl-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate