ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate

Base Information

Chemical Name:ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate
CAS No.:156979-40-7
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate

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Chemical Property of ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate

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Technology Process of ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate

There total 2 articles about ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-49-7
1-ethenylcyclohexene

: 81357-07-5
diethyl (acetylimino)malonate

: 156979-40-7
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate

Guidance literature:: With n-butyllithium; Yield given; 1.) THF, hexane, -78 deg C, 4 h;
DOI:10.1016/0040-4039(95)02284-8

Reference yield:

: 609-09-6
Diethyl ketomalonate

: 156979-40-7
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(1-cyclohexen-1-yl)-3-butynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 12 h / Heating

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / 3 h / -78 °C

With n-butyllithium; In tetrahydrofuran;
DOI:10.1248/cpb.54.196