N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide

Base Information

Chemical Name:N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide
CAS No.:1192477-79-4
Molecular Formula:C₂₀H₂₅N₃O₄
Molecular Weight:371.436
Hs Code.:

Synonyms:N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide

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Chemical Property of N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide

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Technology Process of N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide

There total 6 articles about N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1192476-88-2
{cyclohexylmethyl-[2-(6-methoxy-1H-indol-3-yl)-2-oxo-acetyl]amino}acetic acid

: 1192477-79-4
N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide

Guidance literature:: With ammonia; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1192477-79-4
N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0.5 h / 20 °C

1.2: 24 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydroxide / water

4.1: 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; ammonia; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 18 h / 20 °C

With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1192477-67-0
{cyclohexylmethyl-[2-(6-methoxy-1H-indol-3-yl)-2-oxoacetyl]amino}acetic acid ethyl ester

: 1192477-79-4
N-carbamoylmethyl-N-cyclohexylmethyl-2-(6-methoxy-1H-indol-3-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water

2: 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; ammonia; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 18 h / 20 °C

With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; ammonia; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide;