N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide

Base Information

Chemical Name:N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide
CAS No.:1427162-28-4
Molecular Formula:C₁₈H₂₃N₅O₂S
Molecular Weight:373.479
Hs Code.:

Synonyms:N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide

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Chemical Property of N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide

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Technology Process of N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide

There total 4 articles about N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

: 109-01-3
1-methyl-piperazine

: 1427163-25-4
C₁₃H₁₂ClN₃O₂S

: 1427162-28-4
N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide

Guidance literature:: With potassium carbonate; potassium iodide; In tetrahydrofuran; at 60 ℃; for 1h;
DOI:10.2174/157340612801216418

Reference yield:

: 1353659-91-2
2-amino-N-(4-methylphenyl)-5-thiazolecarboxamide

: 1427162-28-4
N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran / 3.08 h / 0 - 60 °C

2: potassium carbonate; potassium iodide / tetrahydrofuran / 1 h / 60 °C

With potassium carbonate; potassium iodide; In tetrahydrofuran;
DOI:10.2174/157340612801216418

Reference yield:

: 1353659-90-1
(E)-3-ethoxy-N-(4-methylphenyl)acryamide

: 1427162-28-4
N-(4-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido)thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; water / 1,4-dioxane / 3 h / -10 - 22 °C

2: 1,4-dioxane / 2 h / 22 - 80 °C

3: potassium carbonate / tetrahydrofuran / 3.08 h / 0 - 60 °C

4: potassium carbonate; potassium iodide / tetrahydrofuran / 1 h / 60 °C

With N-Bromosuccinimide; water; potassium carbonate; potassium iodide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.2174/157340612801216418