1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol

Base Information

Chemical Name:1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol
CAS No.:1415686-16-6
Molecular Formula:C₂₇H₃₄INO₂Si
Molecular Weight:559.562
Hs Code.:

Synonyms:1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol

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Chemical Property of 1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol

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Technology Process of 1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol

There total 4 articles about 1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₂INO₂Si

: 1415686-16-6
1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1.2h;
DOI:10.1021/ol303036j

Reference yield:

: 88075-18-7
4-(2-(trimethylsilyl)ethynyl)phenol

: 1415686-16-6
1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.28 h / 0 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

3.2: 2.67 h / -78 - 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / ethanol / 1.2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol303036j

Reference yield:

: 550373-07-4
1-ethynyl-4-(triisopropylsilyloxy)benzene

: 1415686-16-6
1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

1.2: 2.67 h / -78 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 1.2 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/ol303036j