8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one

Base Information

Chemical Name:8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one
CAS No.:1374876-46-6
Molecular Formula:C₂₅H₂₆N₄O
Molecular Weight:398.508
Hs Code.:

Synonyms:8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one

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Chemical Property of 8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one

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Technology Process of 8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one

There total 10 articles about 8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1374876-28-4
8-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one trifluoroacetate

: 113118-84-6
5-phenyl-3-pyridinecarboxaldehyde

: 1374876-46-6
8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: 8-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one trifluoroacetate; 5-phenyl-3-pyridinecarboxaldehyde; With triethylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; for 6h;
DOI:10.1515/znb-2012-0113

Reference yield:

: 1374876-30-8
tert-butyl 4-(2-(benzyloxy)quinolin-8-yl)piperazine-1-carboxylate

: 1374876-46-6
8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 2585.81 Torr

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 h / 3361.55 Torr

3.1: dichloromethane / 6 h / 0 - 20 °C

4.1: triethylamine / 1,2-dichloro-ethane / 0 - 20 °C

4.2: 6 h

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1515/znb-2012-0113

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 1374876-46-6
8-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; acetic acid / 2.5 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / Inert atmosphere; Reflux

3.1: triethylamine / 1,2-dichloro-ethane / 0 - 20 °C

3.2: 6 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; acetic acid; triethylamine; In ethanol; water; 1,2-dichloro-ethane; toluene; 2.1: Suzuki coupling;
DOI:10.1515/znb-2012-0113