2-Furancarboxylicacid,3-fluorotetrahydro-5-methyl-,[2R-(2alpha,3beta,5alpha)]-(9CI)

Base Information

Chemical Name:2-Furancarboxylicacid,3-fluorotetrahydro-5-methyl-,[2R-(2alpha,3beta,5alpha)]-(9CI)
CAS No.:121911-25-9
Molecular Formula:C₆H₉FO₃
Molecular Weight:148.134
Hs Code.:
Mol file:121911-25-9.mol

Synonyms:2-Furancarboxylicacid,3-fluorotetrahydro-5-methyl-,[2R-(2alpha,3beta,5alpha)]-(9CI)

Suppliers and Price of 2-Furancarboxylicacid,3-fluorotetrahydro-5-methyl-,[2R-(2alpha,3beta,5alpha)]-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Furancarboxylicacid,3-fluorotetrahydro-5-methyl-,[2R-(2alpha,3beta,5alpha)]-(9CI)

Chemical Property:

PSA：46.53000
LogP:0.58650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Furancarboxylicacid,3-fluorotetrahydro-5-methyl-,[2R-(2alpha,3beta,5alpha)]-(9CI)

There total 4 articles about 2-Furancarboxylicacid,3-fluorotetrahydro-5-methyl-,[2R-(2alpha,3beta,5alpha)]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121911-20-4
(2S,3R,5S,R_S)-3-fluoro-2-(p-tolylsulphinylmethyl)-5-methyltetrahydrofuran

: 121911-25-9
(2R,3R,5R)-3-fluoro-5-methyltetrahydrofuran-2-carboxylic acid

Guidance literature:: With 2,4,6-trimethyl-pyridine; sodium chlorite; dipotassium hydrogenphosphate; 2-methyl-but-2-ene; trifluoroacetic anhydride; mercury dichloride; Yield given. Multistep reaction; 1.) MeCN, room temperature; water, 2.) t-butyl alcohol;

Reference yield:

: 121911-13-5
(2S,3R)-3-fluoro-1(R)-<(4-methylphenyl)sulfinyl>-5-hexen-2-ol

: 121911-25-9
(2R,3R,5R)-3-fluoro-5-methyltetrahydrofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) mercury(II) trifluoroacetate; potassium chloride, 2.) sodium borohydride / 1.) THF, 0 deg C; water, 30 min, 2.) CH₂Cl₂, 0 deg C

2: 1.) trifluoroacetic anhydride, 2,4,6-trimethylpyridine; mercury(II) chloride, 2.) sodium chlorite, potassium hydrogen phosphate, 2-methylbut-2-ene / 1.) MeCN, room temperature; water, 2.) t-butyl alcohol

With 2,4,6-trimethyl-pyridine; sodium chlorite; sodium tetrahydroborate; dipotassium hydrogenphosphate; 2-methyl-but-2-ene; potassium chloride; mercury(II) trifluoroacetate; trifluoroacetic anhydride; mercury dichloride;

Reference yield:

: 121911-10-2
(3R)-3-fluoro-1(R)-<(4-methylphenyl)sulfinyl>-5-hexen-2-one

: 121911-25-9
(2R,3R,5R)-3-fluoro-5-methyltetrahydrofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent

2: 1.) mercury(II) trifluoroacetate; potassium chloride, 2.) sodium borohydride / 1.) THF, 0 deg C; water, 30 min, 2.) CH₂Cl₂, 0 deg C

3: 1.) trifluoroacetic anhydride, 2,4,6-trimethylpyridine; mercury(II) chloride, 2.) sodium chlorite, potassium hydrogen phosphate, 2-methylbut-2-ene / 1.) MeCN, room temperature; water, 2.) t-butyl alcohol

With 2,4,6-trimethyl-pyridine; sodium chlorite; sodium tetrahydroborate; dipotassium hydrogenphosphate; 2-methyl-but-2-ene; potassium chloride; mercury(II) trifluoroacetate; trifluoroacetic anhydride; mercury dichloride;