methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

Base Information

Chemical Name:methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate
CAS No.:1014645-22-7
Molecular Formula:C₂₂H₂₀ClNO₃S
Molecular Weight:413.925
Hs Code.:

Synonyms:methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

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Chemical Property of methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

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Technology Process of methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

There total 2 articles about methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1014645-18-1
4-(3-chlorobenzyl)thiophene-3-carboxylic acid

: methyl (S)-4-(1-aminoethyl)benzoate hydrochloride

: 1014645-22-7
methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/jm901771h

Reference yield:

: 1014645-22-7
methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

Guidance literature:

Reference yield: 90.0%

: 1014645-22-7
methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

: 4-[(1S)-1-[[[4-[(3-chlorophenyl)methyl]-3-thienyl]carbonyl]amino]ethyl]benzoic acid

Guidance literature:: methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 60h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm901771h