7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol

Base Information

Chemical Name:7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol
CAS No.:1364686-87-2
Molecular Formula:C₁₈H₁₉BClNO₆
Molecular Weight:391.616
Hs Code.:

Synonyms:7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol

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Chemical Property of 7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol

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Technology Process of 7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol

There total 5 articles about 7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 75-52-5
nitromethane

: 1364686-80-5
3-(3-benzyloxy-propoxy)-5-chloro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzaldehyde

: 1364686-87-2
7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol

Guidance literature:: nitromethane; 3-(3-benzyloxy-propoxy)-5-chloro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzaldehyde; With sodium hydroxide; cetyltrimethylammonim bromide; In tetrahydrofuran; for 12h;

With hydrogenchloride; In tetrahydrofuran; water; pH=1;

Reference yield:

: 73275-96-4
5-chloro-2,3-dihydroxy-benzaldehyde

: 1364686-87-2
7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h

1.2: 0 °C

2.1: pyridine / dichloromethane / 3.08 h / 0 - 20 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: sodium hydroxide / cetyltrimethylammonim bromide / tetrahydrofuran / 12 h

4.2: pH 1

With pyridine; potassium acetate; sodium hydride; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cetyltrimethylammonim bromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; mineral oil;

Reference yield:

: 1364686-66-7
3-(3-benzyloxy-propoxy)-5-chloro-2-hydroxy-benzaldehyde

: 1364686-87-2
7-(3-benzyloxy-propoxy)-5-chloro-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 3.08 h / 0 - 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

3.1: sodium hydroxide / cetyltrimethylammonim bromide / tetrahydrofuran / 12 h

3.2: pH 1

With pyridine; potassium acetate; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cetyltrimethylammonim bromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;