[(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester

Base Information

• Chemical Name: [(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester
• CAS No.: 81278-18-4
• Molecular Formula: C₂₈H₂₉NO₄
• Molecular Weight: 443.543
• Mol file: 81278-18-4.mol

Synonyms:[(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester

Chemical Property of [(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester

There total 2 articles about [(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2--4,4-dimethyl-Δ2-oxazoline (81278-33-3) → [(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester (81278-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) methyl iodide, 2.) aq. sodium hydroxide / 1.) reflux, 20 h, 2.) THF, reflux, 26 h

2: 1.) oxalyl chloride, N,N-dimethylformamide, 2.) triethylamine / 1.) ether, 5 deg C, 20 h, 2.) benzene, reflux, 24 h

With sodium hydroxide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; methyl iodide;

DOI:10.1021/jo00133a041

Reference yield:

ethyl N-phenyl-α-phenylglycinate (940866-95-5) + p-methoxy-o-(3-butenyl)benzoic acid (81278-32-2) → [(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester (81278-18-4)

Guidance literature:

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1.) ether, 5 deg C, 20 h, 2.) benzene, reflux, 24 h;

DOI:10.1021/jo00133a041

Reference yield: 78.0%

[(2-But-3-enyl-4-methoxy-benzoyl)-phenyl-amino]-phenyl-acetic acid ethyl ester (81278-18-4) → N-phenyl-N--2-phenylglycine (81278-17-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.5h; Heating;

DOI:10.1021/jo00133a041

upstream raw materials:

ethyl N-phenyl-α-phenylglycinate

p-methoxy-o-(3-butenyl)benzoic acid

2--4,4-dimethyl-Δ²-oxazoline

Downstream raw materials:

N-phenyl-N--2-phenylglycine

1,2-diphenyl-7-methoxy-4,5-dihydro-1H-benzindole

1,5-diphenyl-2--3,4-bis(carbomethoxy)pyrrole